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Introduction: Several clinical trials have
demonstrated that low-level light therapy
(LLLT), a method of photobiomodulation, is an
effective analgetic treatment. However, the
mechanism of action has not yet been finally
clarified. In particular, unanswered questions
include whether it only affects peripheral or
whether it also affects the spinal or supraspinal
level. This study aimed to evaluate the effect of
low-level light therapy on primary and sec-
ondary hyperalgesia in a human pain model.
Methods: This study was planned as a ran-
domized, sham-controlled, and double-blinded
trial with repeated measures within subject
design. Capsaicin was applied on both forearms
of ten healthy volunteers to induce peripheral
and central sensitization. One forearm was
treated with low-level light therapy; the other
served as sham control.
Results: Low-level light therapy significantly
increased the mechanical pain threshold, heat
pain threshold, and decreased pain intensity.
Conclusions: Our data indicate that low-level
light therapy is effective at reducing the heat
and mechanical pain threshold in a human
pain model, pointing to a significant modulat-
ing effect on peripheral and central sensitiza-
tion. These effects—especially in the absence of
reported side effects—make low-level light
therapy a promising tool in pain management.
The application of low-level light therapy to
treat chronic pain should be considered for
further clinical trials.
Study:
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